Prostacyclin

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Prostacyclin and vascular disease

We hypothesize tha t prostacyclin (PG I2) is an anti-atherosclerotic hormone and that atherosclerosis develops when endothelial P G I2 synthetase is inhibited by lipid peroxides. Serum lipid peroxides occur in low-density lipoproteins (LDL). LDL lipid peroxides are elevated in common types of hyperlipoproteinaemias, P G I2 generation is im paired in atherosclerosis, and infusion of synthetic P ...

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Oxygen Modulates Prostacyclin Synthesis

Prostacyclin (PGI2) plays an integral role in 02 mediation of pulmonary vasomotor tone in the fetus and newborn. We hypothesized that 02 modulates PG!2 synthesis in vitro in ovine fetal intrapulmonary arteries, with decreasing 02 causing attenuated synthesis. A decline in Po2 from 680 to 40 mmHg caused a 26% fall in basal PGI2 synthesis. PGI2 synthesis maximally stimulated by bradykinin, A23187...

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Prostacyclin and vascular disease

We hypothesize tha t prostacyclin (PG I2) is an anti-atherosclerotic hormone and that atherosclerosis develops when endothelial P G I2 synthetase is inhibited by lipid peroxides. Serum lipid peroxides occur in low-density lipoproteins (LDL). LDL lipid peroxides are elevated in common types of hyperlipoproteinaemias, P G I2 generation is im paired in atherosclerosis, and infusion of synthetic P ...

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Prostacyclin: An Inflammatory Paradox

Prostacyclin (PGI(2)) is a member of the prostaglandin family of bioactive lipids. Its best-characterized role is in the cardiovascular system, where it is released by vascular endothelial cells, serving as a potent vasodilator and inhibitor of platelet aggregation. In recent years, prostacyclin (PGI(2)) has also been shown to promote differentiation and inhibit proliferation in vascular smooth...

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Prostacyclin among prostanoids.

Prostanoids are cyclic lipid mediators which arise from enzymic cyclooxygenation of linear polyunsaturated fatty acids, e.g. arachidonic acid (20:4 n 6, AA). Biologically active prostanoids deriving from AA include stable prostaglandins (PGs), e.g. PGE(2), PGF(2alpha), PGD(2), PGJ(2) as well as labile prostanoids, i.e. PG endoperoxides (PGG(2), PGH(2)), thromboxane A(2) (TXA(2)) and prostacycli...

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ژورنال

عنوان ژورنال: Journal of the Royal Society of Medicine

سال: 1983

ISSN: 0141-0768,1758-1095

DOI: 10.1177/014107688307600401